Category: cfzcwphz

Myogenic cell cycle duration in Harpagifer species with sub-Antarctic and Antarctic distributions: evidence for cold compensation

first_imgIn teleosts, the proliferation of myogenic progenitor cells is required for muscle growth and nuclear turnover. We measured the cell cycle and S-phase duration of myogenic cells in the fast myotomal muscle of two closely related Harpagifer species by cumulative S-phase labelling with 5-bromo-2′-deoxyuridine (BrdU). Harpagifer antarcticus is a stenothermal species from the Antarctic peninsula (experiencing temperatures of -2degreesC to +1degreesC) and Harpagifer bispinis is a eurythermal species from the Beagle Channel, Tierra del Fuego (living at +4degreesC in winter and up to 11degreesC in summer). Specific growth rates in the adult stages studied were not significantly different from zero. Myogenic progenitor cells were identified using an antibody against c-met. Seventy-five percent of the c-met(+ve) cells were in a proliferative state in both species. Cell cycle time was 150h at 5degreesC and 81.3h at 10degreesC in H. bispinis (Q(10)=3.4). Cell cycle duration was 35% shorter in H. antarcticus at 0degreesC (111h) than in H. bispinis at 5degreesC. The predicted cell cycle time for H. bispinis at 0degreesC (based on the Q(10) relationship) was 277h, which was more than double that measured for the Antarctic species at this temperature. The results obtained are compatible with an evolutionary adjustment of cell cycle time for function at low temperature in the Antarctic specieslast_img read more

Guest blog: ‘Has the latest lockdown finally cooled the market?’

first_imgHome » News » Agencies & People » Guest blog: ‘Has the latest lockdown finally cooled the market?’ Guest blog: ‘Has the latest lockdown finally cooled the market?’Steve Wayne has seen a significant dip in activity in recent days and wonders if the Covid downturn has begun tempering the recent boom.Steve Wayne, MD, Benjamin Stevens11th November 20202 Comments1,274 Views As the second national lockdown was announced last Saturday night, I sat at home with my wife and daughters and we just assumed, along with most of you, that we would have to close our branches again like agencies have been forced to do in Wales and the same as during the first lockdown.A few hours later and a few vague tweets which we all had to ‘read between the lines’, we released that people would still be able to move, which to me, made good sense.Then the news started to circulate that we could stay open and operate as normal, well – as ‘normal’ as anything is nowadays. Immediately this worried me.Why had the world been placed on pause again while we as estate agencies were allowed to keep going?Housing marketNow I understand the value the housing market has to the government and the economy, but to me it made no sense that, even with all our high levels of COVID health and safety procedures we have implemented, we can still go house to house with clients who have been who knows where doing who knows what!My other concern was whether business would maintain its level of craziness of the last few months, or even pre-lockdown normal?I feared for the worse and asked myself why would anyone who can’t see their friends or families want to let in random strangers into their homes?Everyone has been told to stay home under tight restrictions, and yet people with properties on the market are now getting estate agents, who aren’t the most popular of industries in the first place, calling up and saying “it’s ok, we are exempt”.I’ve been running my agency, Benjamin Stevens Estate Agents for just over 16 years, and just in the first few days of this most recent lockdown, we’ve seen the public have spoken with their feet.Everyone I’ve spoken to including fellow agents and industry leaders have all seen a sudden and alarming dip in calls, viewing requests and activity.Tough monthsOf course some are still busy with some great listings and that will always bring activity, but no one can deny a change, that coupled with the usual slowdown over December and early January, indicates it’s going to be a tough few months before spring returns and people start to feel comfortable again being out and about.As business owners we have the use of furlough but now, like kids in a playground, we need to pick our strongest team and potentially offend some of our loyal staff, when what we are actually doing is preserving their futures.It could be argued we should have money for a rainy day but in my view we shouldn’t be open when so many others can’t be.  Why should we be allowed to work when so many can’t?Ultimately the last thing people who have been furloughed and fearing their job security will be thinking about right now, is moving.Read more about Benjamin Stevens.lockdown Benjamin Stevens Steve Wayne 2020-11-11Nigel Lewis2 commentsJames Gibbs, Gibbs Gillespie Gibbs Gillespie 11th November 2020 at 9:52 amHome movers sometimes have to move for all types of reasons, not just on a whim. The housing market is massively important to an economy, the alternative to the Govt spending £billions more on furloughing is massive unemployment and look at all the problems that brings.Log in to ReplyJulian Blackmore, BNE BNE 11th November 2020 at 9:12 amThe fuse has been litLog in to ReplyWhat’s your opinion? Cancel replyYou must be logged in to post a comment.Please note: This is a site for professional discussion. Comments will carry your full name and company.This site uses Akismet to reduce spam. Learn how your comment data is processed. Related articles BREAKING: Evictions paperwork must now include ‘breathing space’ scheme details30th April 2021 City dwellers most satisfied with where they live30th April 2021 Hong Kong remains most expensive city to rent with London in 4th place30th April 2021last_img read more

Rugby star trio set up estate agency in sport’s Welsh capital

first_imgThree Rugby stars have launched the latest branch of national estate agency Nexa in the Welsh capital of the sport, Cardiff, promising to turn the property industry ‘on it head’.The estate agency has been founded by Olly Kohn (top, left), Rob Higgitt (middle) and Joe El-Abd (right). Between them had successful Rugby careers at regional, national and international levels, and is part of the national growing Nexa branch of estate agencies with offices inKohn is arguable the more famous Rugby Union player of the three. As well as playing for Bristol, Plymouth and Harlequins as a lock forward, in 2013 he was called up to play for Wales in that year’s Six Nations, which the squad went on to win.Kohn had to retire due to injury soon afterwards, but prior to the competition he courted controversy after claiming Welsh heritage through his grandfather to be eligible for the squad.Higgitt and El-Abd are also former Bristol players. Higgitt was a star member of the squad’s defensive line during the late noughties, while El-Abd was a well-known flanker-turned-coach for the club and possesses legendary status in Bristol with over 100 appearances including some as captain.The trio are promising to disrupt the estate agency scene and already have a sizeable portfolio of rental properties owned by current and former Welsh rugby players.They have also recruited Oliver Griffiths (pictured) as the firm’s senior client director. He recently return to Cardiff after a five-year stint working for Jackson-Staffs in Richmond, Surrey.Nexa, which has six other territories including in Bristol, Lilverpool, Portsmouth and Chichester, offers vendors and landlords a dedicated client director to look after their transactions which, it says, sets the company apart from other agencies.“Too often in the property market, the refined service is given to high-value properties and developers; leaving renters, landlords, and lower value properties left in the dust to receive an inconsistent, pass-around service,” says Kohn.“I am over the moon to be a part of a company that is revolutionising UK estate agencies and providing solutions to the frustrations you typically see in the industry.”Read about other former Rugby stars in the industry.nexa Olly Kohn Rob Higgitt Joe El-Abd March 19, 2021Nigel LewisOne commentJohn Durrant, Doctor Photo Doctor Photo 19th March 2021 at 9:31 amCouldn’t agree more with the sentiment that lower-value homes aren’t always given enough consideration. When you think that cornflakes (a couple of quid) come in a brightly coloured box but a house of £100k (perhaps someone’s most valuable asset) will sometimes be photographed from the agent’s car window, not even bothering to get out of the car. However, the industry IS changing. More agents now than ever before have realised that it’s not just the property that suffers when they are shoddy, but their brand as well! Amen to that.Log in to ReplyWhat’s your opinion? Cancel replyYou must be logged in to post a comment.Please note: This is a site for professional discussion. Comments will carry your full name and company.This site uses Akismet to reduce spam. Learn how your comment data is processed.Related articles BREAKING: Evictions paperwork must now include ‘breathing space’ scheme details30th April 2021 City dwellers most satisfied with where they live30th April 2021 Hong Kong remains most expensive city to rent with London in 4th place30th April 2021 Home » News » Agencies & People » Rugby star trio set up estate agency in sport’s Welsh capital previous nextAgencies & PeopleRugby star trio set up estate agency in sport’s Welsh capitalThree players with regional, national and international rugby careers say they want to disrupt the property market.Nigel Lewis19th March 20211 Comment642 Viewslast_img read more

Hospital Cuts Expenses to Offset Coronavirus Costs

first_imgBy MADDY VITALEShore Medical Center in Somers Point is asking employees to take voluntary layoffs and will also cut executive salaries as cost-saving measures in the wake of the coronavirus pandemic.A letter dated March 30 sent to Shore employees from the Human Resources Department explained a reduction in staff hours. It also noted that if any employees are interested in leaving the company prior to involuntary layoffs, they should contact their managers.“Nothing is more important than the safety of our staff and the ability to provide the highest level of care to our patients,” Shore Medical Center spokesman Brian Cahill said. “We are providing and will continue to provide our clinical teams on the front line with everything they need to treat our patients and remain safe.”The intended volunteers for reduction are in non-clinical support areas that have nothing to do with patient care. No doctors or nurses will be granted a volunteer layoff, Cahill said.He also said that the hospital did not want to exclude someone who may have extenuating circumstances that would prevent them from providing care to patients with COVID-19.In addition, Shore Medical Center’s CEO and all senior executives volunteered to take a pay cut ranging from 25 to 35 percent of their salary to offset some of the “massive expenses” the hospital is facing due to COVID-19, Cahill said. Shore Medical Center is closing off visitors to the hospital due to the uptick in COVID-19 cases in the region.last_img read more

Guidance: Small and medium-sized enterprise action plan

first_imgThe plan sets out the activities that will take place to support SMEs during the department’s procurement processes. The action plan supports the government’s aspiration that 33% of procurement spend will go to SMEs by March 2022.last_img

Colorful clones track stem cells

first_img Medical hope on horizon Stem cell science aids therapies for diabetes, ALS, other diseases, HUBweek panelists say Related Harvard Stem Cell Institute (HSCI) researchers have used a colorful cell-labeling technique to track the development of the blood system and trace the lineage of adult blood cells traveling through the vast networks of veins, arteries, and capillaries back to their parent stem cells in the marrow.Developed at Harvard’s Center for Brain Science, the technique involves coding multiple colors of fluorescent protein into a cell’s DNA. As genes recombine inside the cell, the cell elaborates a color unique to its genetic code. For blood stem cells, that color becomes a genetic signature passed down to daughter cells; purple stem cells, for example, will only make purple blood cells.Two independent research teams, one led by David Scadden, HSCI co-director and Gerald and Darlene Jordan Professor of Medicine at Harvard University, and the other by his colleague Leonard Zon, HSCI Executive Committee member and director of the Stem Cell Program at Boston Children’s Hospital, adapted the color-based labeling to the blood system to better understand how blood stem cells behave.In a study recently published in Cell, a research team led by Scadden found that in mice individual blood stem cells had a specific and restricted blood production repertoire. “We used to think of stem cells as the mother cell that gives rise to all these other cells in the system on an as-needed basis,” said Vionnie Yu, first author of the study and, at the time of the research, a postdoctoral fellow in Scadden’s lab. But their results suggest that stem cells have a scripted set of responses and cannot make just any blood cell type.When transplanted into a new environment, each cell not only consistently made the same mature blood cell types but also the same number of those cells. Additionally, clones responded similarly to inflammatory and chemotoxic stress, suggesting the cells had a hardwired memory dictating their behavior. They found that this memory was written into the stem cell epigenome.Blood stem cells, said Scadden, may be more like chess pieces with a fixed way they can behave within the system.“When you are young and have a full chess set you can mount a vigorous and multilayered defense to an attack on your system,” Scadden said, “but if you lose chess pieces with age or you don’t receive a full suite of players during a bone marrow transplant, the pieces you have left could determine your ability to protect yourself.”In addition to looking at blood stem cells in adult mice, color tagging also allows researchers to explore the blood system as a zebrafish embryo develops.“We’ve been working with David Scadden for years as part of the HSCI. Initially, we presented our work at a joint lab meeting and realized we could study stem cell clones with this multicolor system,” said Zon, who is also a professor in Harvard’s Stem Cell and Regenerative Biology department. “We shared ideas and results, and even wrote a grant together on the topic. It is wonderful that studying clonal dynamics in two different animals could provide such complementary information.”In a study published Monday in Nature Cell Biology, the researcher team led by Zon used the color-tagging system to find the origin and number of stem cells that contribute to lifelong blood production.About 24 to 30 hours after fertilization, dozens of stem cells budded off from the dorsal side of the aorta. Only 20 made it to a secondary site before heading to the kidney marrow, the zebrafish equivalent to human and mouse bone marrow.After transplanting the multicolored marrow into fish that had received sublethal doses of radiation, the researchers found that some blood stem cell lineages supplied a greater proportion of blood than they had before and that certain lineages could survive harsher conditions than others.Knowing which cells are responsible for blood production could have implications for understanding the development of blood cancers, explained Jonathan Henninger, a graduate student in Zon’s lab at Boston Children’s Hospital and first author in the study.For example, one cell could develop a mutation that gives it a competitive edge, allowing it to take over the blood system.“If that cell starts behaving badly, it could lead to blood disorders, such as myeloid dysplasia and leukemia,” Henninger said.Researchers know these disorders come from a single stem cell or a downstream progenitor cell, said Henninger, but right now they are looking at populations of stem cells in bulk. “To be able to identify that single cell that went awry could help us better understand these diseases.”last_img read more

Lessons of the Week! Neil Patrick Harris, Lesli Margherita & More

first_img Star Files View Comments Before you cut out of work early and head to the beach for some much-needed relaxation time—wait, what? It’s still freezing outside? Oh, whoops. Let’s try this again. Before you cut out of work early and head to your couch for a much-needed Netflix-and-Snuggie fest, let’s learn something from the crazy, strange and totally weird stuff that happened on Broadway this week. Ready? Let’s go!NPH Can’t Finish a SandwichJared Leto—uh, we mean Hedwig star Neil Patrick Harris—has lost 20 pounds for his new role, and on GMA, he joked about being “manorexic” and only eating a few bites of his lunch. Stop it, Neil. Finish that sandwich. It’s what Miss Hedwig would want.James Franco Collects Ticket StubsOf Mice and Men star James Franco has yet another hobby we didn’t know about: He collects ticket stubs from every Broadway show he’s seen. Aww, that’s so cute! You know what’s not as cute? Cursing out a critic on Instagram. (P.S. Need to talk? Call us. We’re here for you.)Queen Will Rock You…AgainIf you’ve ever wondered happens to Galileo, Scaramouche and their pals after the Queen jukebox musical We Will Rock You ends, you’re in luck, because Brian May is working on a sequel. Does Meat get cooked? Does Adam Lambert star? Will we ever figure out the plot? Did we mention Adam Lambert?!The Threepenny Cast Is StarvingWhen Laura Osnes took us backstage at The Threepenny Opera, she and her castmates spent a lot of time talking about 16 Handles (duh), cupcakes, brownies, peanut butter (twice) and cheese. Guys, take a field trip to the Belasco—we hear NPH has sandwiches.James Monroe Iglehart Makes Sh*t UpHow did Aladdin funny guy James Monroe Iglehart score the role of the Genie? By completely ignoring the script and making up his own lines at his audition, saying pretty much whatever he wanted. Guys, this is a really good thing to try when you audition for your high school play.Lesli Margherita Needs a BodyguardMatilda star Lesli Margherita had a super-giant Q&A (Q&AAA, Q&AAA…) session on her video blog this week, and what did we learn? Well, that some of her fans are a little, uh, stalkery. As it turns out, everyone wants to be the Queen—even this guy.Steven Pasquale Does Carol ChanningWe knew Bridges star Steven Pasquale has a great voice and looks fantastic with his shirt off, but did you know he can do impressions? On Side By Side, he channeled Mandy Patinkin, Carol Channing, Jim Carrey and a ton more. Quick, someone write a musical adaptation of The Mask! Pasek? Paul?The Obamas Made Us LateThe President and First Lady had a date night last Friday, and instead of their usual trip to the Olive Garden, they decided it would be fun to see a Broadway show. Meanwhile, after struggling to get past the police barricades and blocked-off streets, every other ticketholder said “f*ck it” and went to the Olive Garden.Will Swenson Licks (& Likes) His WifeLes Miz star Will Swenson was the newest victim of autocorrect this week, when a text reading “I like my wife” was suddenly changed to “I lick my wife.” (Swenson did admit, however, that this statement is also true.) Quoth the Wee Posse of Three: “Eww!”Audra McDonald Shoots CatsSpeaking of Will Swenson’s liked and licked wife, Lady Day star Audra McDonald told us her pre-show warm-up is so weird, people must think she’s “shooting cats.” Wait, did you say you’re shooting Cats? The movie!? OMG, OMG, OMG. Are you Grizabella or Gumbie Cat?center_img Lesli Margheritalast_img read more

Omaha utility proposing faster shift from coal to renewables

first_img FacebookTwitterLinkedInEmailPrint分享Associated Press:Omaha Public Power District is proposing more aggressive environmental goals to get electricity from renewable sources and natural gas.The electric utility’s board may vote next week on a new set of goals that would accelerate its shift away from coal to other power sources, the Omaha World-Herald reported. The utility is considering a policy change that would reduce the amount of carbon released while producing each megawatt of electricity for ratepayers.The change could increase the pace at which OPPD adopts wind and solar power projects with private providers, said Craig Moody, a utility board member who supports the proposed approach to environmental stewardship.The move would break from the utility’s approach since 2015, which focused on generating a certain percentage of local electricity from renewable sources.The draft policy calls for a 20 percent reduction in “carbon intensity” levels from 2010 to 2030. Choosing 2010 instead of 2017 for the baseline year for progress would require more carbon reductions. In 2010, the utility still operated Fort Calhoun Nuclear Station, a carbon-free source of energy that has since shuttered.More: Omaha electric utility proposes new environmental goals Omaha utility proposing faster shift from coal to renewableslast_img read more

Army Deploying ‘Individual Gunshot Detector’

first_imgBy Dialogo March 21, 2011 U.S. Army forces in Afghanistan will begin receiving the first of more than 13,000 gunshot detection systems for the individual dismounted Soldier later this month, service officials said. “We’re really trying to ensure that every Soldier is protected,” said Brig. Gen. Peter Fuller, Program Executive Officer Soldier. The Individual Gunshot Detector, or IGD – made by QinetiQ North America – consists of four small acoustic sensors worn by the individual Soldier and a small display screen attached to body armor that shows the distance and direction of incoming fire. The small sensor, about the size of a deck of cards, detects the supersonic sound waves generated by enemy gunfire and instantaneously alerts Soldiers to the location and distance toward the hostile fire, said Lt. Col. Chris Schneider, product manager for Soldier Maneuver Sensors. “When you get fired on, instead of trying to figure everything out, you will have technology to assist you in knowing what happened and where the shot was coming from,” Fuller said. The entire IGD system, procured by PEO Soldier and the Army’s Rapid Equipping Force, weighs less than two pounds, Schneider said. The idea is to strategically disperse the systems throughout small, dismounted units to get maximum protective coverage for platoons, squads and other units on the move, Schneider explained. Over the next 12 months, the Army plans to field up to 1,500 IGDs per month, he said. In the future, the Army plans to integrate this technology with its Land Warrior and Nett Warrior systems. These are network-situational-awareness systems for dismounted units, complete with a helmet-mounted display screen that uses GPS digital-mapping-display technology, Fuller said. “The next thing we want to do is try to integrate this capability with other capabilities; for example, we have Land Warrior deployed in Afghanistan and we’re going to have Nett Warrior coming into the force. How about, if you get shot at, not only do I know where that came from, but others know where it came from because I can network that capability,” said Fuller. “It’s about how to leverage technology to improve your survivability and situational awareness.”last_img read more

NAFCU announces new 2019-2020 board

first_img ShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblr continue reading » NAFCU yesterday announced its 2019-2020 Board of Directors, on the opening day of its 52nd Annual Conference and Solutions Expo in New Orleans.“This is an exciting time for NAFCU and the credit union industry,” said Jeanne Kucey, NAFCU’s board chair and president and CEO of JetStream Federal Credit Union. “I look forward to building upon a successful 2019 and working alongside my board colleagues as NAFCU continues to advocate on behalf of the credit union industry and its 117 million members.”NAFCU officers for 2019-2020 are:​Jeanne Kucey, chair and Southern Region Director – president and CEO of JetStream Federal Credit Union in Miami Lakes, Fla.;Debra Schwartz, vice chairman and Director-at-Large – president and CEO of Mission Federal Credit Union in San Diego, Calif.;Thomas W. DeWitt, treasurer and Western Region Director – president and CEO of State Farm Federal Credit Union in Bloomington, Ill.; andlast_img read more